Study on the effect of tunicate cellulose nanocrystals in the preparation of sodium alginate-based enteric capsule

In this work, tunicate cellulose nanocrystals (tCNCs) were extracted from the by bleaching and acid hydrolysis. They used as filler in preparation of sodium alginate-based enteric capsules. The addition tCNCs with a high aspect ratio (65) rendered capsule excellent physical properties. Compared control sample, when 10% (wt), water contact angle was enhanced 46.0%, opacity increased 356.8%, maximum tensile stress 142.6%, modulus elasticity 240.3%, elongation at break 133.8%. vitro degradation experiments, hardly degraded gastric environment (pH 1.2), while intestinal 6.8), became slower increase tCNC content, which consistent properties capsule. This research developed new direction for application pharmaceutical material productions.